Ksendzovsky Lab

Alex Ksendzovsky, MD, PhD directs a lab that combines electrophysiology and molecular techniques to study the fundamental role metabolism plays in regulating neuronal activation, epilepsy and movement disorders. To do this, his team leverages access to human intracranial recordings during epilepsy monitoring to identify, segregate, and analyze epileptic and normal brain tissue.

When faced with high energy demands, the brain adjusts its metabolic response, yet the cellular basis for how this occurs or if these changes play a role in epilepsy remains unknown.

The Ksendzovsky lab is interested in combining electrophysiology and molecular techniques to study the fundamental role metabolism plays in regulating neuronal activation and epilepsy.

To do this, they leverage access to human intracranial recordings during epilepsy monitoring to identify, segregate and analyze epileptic and normal brain tissue.

These findings are translated into in vitro and in vivo models which they use to explore mechanisms underlying the metabolic control of neuronal activity and epilepsy.